Amyotrophic lateral sclerosis (ALS), often referred to as "Lou Gehrig's Disease," is a progressive neurodegenerative disease that affects nerve cells in the brain and the spinal cord. Aphmau takes on the ALS Ice Bucket Challenge as well as donates $100.00. For more information about ALS as well as where you can go to donate visit: inflnc.us/Timpz. A very powerful ALS video from someone who has experienced it:.