Three years after the events of Uncharted 3: Drake's Deception, Nathan "Nate" Drake, now retired as a fortune hunter, has settled into a normal life with his wife Elena Fisher. His world is then turned upside down when his older brother Sam, long believed to be dead, suddenly reappears seeking Drake's help. Along with Victor "Sully" Sullivan, they embark on a race against time, across the globe, from the snow-capped peaks of Scotland to the island nation of Madagascar, in pursuit of a conspiracy behind Libertalia, a long lost pirate colony, and its fabled pooled pirate treasure..