*Knife Only. The first half hour is collecting the plates and bringing a ton of heals out to the front. The siege begins at 27:30. Isaac Vs 30 Zombies (Very Hard). I envisioned things a little smoother with having a dodge and more heals, but this was not the case. It takes awhile to kill a single zombie with just one hit at a time, so I kept getting interrupted. The sewer and Matthew zombie were the most annoyingly persistent in following me. It's kinda funny when you see these two zombies come out of nowhere, which makes me have to leave and reposition myself all over again. The virus meter is extremely important for this run. I did it twice as Mac and my virus was at 50% at the start of the siege. Both times, my virus reached 100% while I was fighting. With Issac, my virus was considerably lower at the start of the siege. Making more anti-virus was also extremely helpful. Haha, and so was the hemostat. Things almost went to hell RIGHT at the end too. Developer/Publisher: Capcom.